Brazilian cubensis Mushroom

Entheogenic use

Its major psychoactive compounds are:

• Psilocybin (4-Phosphoryloxy-N,N-dimethyltryptamine)
• Psilocin (4-hydroxy-N,N-dimethyltryptamine)
• Baeocystin (4-Phosphoryloxy-N-methyltryptamine)
• Norbaeocystin (4-Phosphoryloxytryptamine)

Individual brain chemistry and psychological predisposition play a significant role in determining appropriate doses. For a modest psychedelic effect, a minimum of one gram of dried Psilocybe cubensis mushrooms is ingested orally. 0.25-1 gram is usually sufficient to produce a mild effect, 1-2.5 grams usually provides a moderate effect. 2.5 grams and higher usually produces strong effects.^[3] For most people, 3.5 dried grams (1/8 oz) would be considered a high dose and may produce an intense experience. For many individuals doses above 3 grams may be overwhelming. For a few rare people, doses as small as 0.25 grams can produce full-blown effects normally associated with very high doses. For most people, however, that dose level would result in virtually no effects. Due to factors such as age and storage method, the psilocybin content of a given sample of mushrooms will vary. Therefore, some users prefer to use a formula or dosage calculator ^[4] to tailor the dosage to the level they wish to experience.

Effects usually start after approximately 20-60 minutes (depending on method of ingestion and stomach contents) and may last from four to five hours, depending on dosage. Hallucinatory effects often occur, including walls that seem to breathe, a vivid enhancement of colors and the animation of organic shapes. At higher doses, experiences tend to be less social and more entheogenic, often intense and spiritual in nature.

It’s nearly impossible to overdose on psilocybin mushrooms since one would have to consume nearly their entire body weight in fresh mushrooms or ≈1680g of dried mushrooms.^[5] Nevertheless, the effects of very high doses can be overwhelming. Depending on the particular strain, growth method, and age at harvest, Psilocybe cubensis mushrooms can come in rather different sizes. It is recommended that one weigh the actual mushrooms, as opposed to simply counting them. People taking MAOIs need to be careful, as psilocybin and psilocin are metabolized by the enzyme monoamine oxidase. An MAOI reduces the body’s ability to handle the mushrooms (roughly doubling their potency), and can lead to an unpleasant, prolonged, or dangerously strong experience.